Methods: analgesic test with water bath, writhes induced by acetic acid, tickling induced by histamine and capillary permeability increase tests were applied. 方法:采用温浴甩尾法和扭体法镇痛试验、毛细血管通透性试验、组胺致瘙痒等药理模型。
Methods: Ebastine 10 mg or 1 tablet of placebo was given to 60 healthy volunteers in randomized, double-blind manner. Histamine titration tests were performed for each volunteer before dosing and 2, 4, and 24 hours after dosing. 方法:60名健康受试者随机、双盲口服依巴斯汀10mg或安慰剂1片,于服药前和服药后2、4、24h,对全部受试者行组胺皮肤点刺滴定试验。